Some, semi-common conditions that affect a good portion of society, and more who are non optimal excercisers: methylation problems (active folate, B12, b6 issues pyrroles (zinc, active b6, gla and some magnesium) (see Walsh protocols for a wide range of conditions from variouse malfunction, including sulphication issues, includes methylation) these are issues common in autism spectrum disorders, with Asperger’s being part of the disorder, I suspect trials on University students that be skewed by this), nor-adrenalin, copper vitamin C, iron or zinc and other issues, and people with ATP dysfunction, such as from the virus associated with chronic fatigue. Either a supplement addresses issues, or the underlying physiology might have to run smoothly to maximise it’s affect.
Hmmmm interesting. Funny you mention it because I was taking gaba not too long ago and it was in a mixture with some other stuff. Anyways, I think it was causing me to wake up kind of uncoordinated and feeling just kind of weird. Dissociative I guess you could say, which makes sense because it’s related to the NMDA receptors somehow I think. It supposedly “can’t” cross the blood brain barrier, at least this is repeated despite the fact that it can and does, it’s just an unreliable mechanism in which it does. Low levels of gaba were insinuated to absorb more in the brain also. I didn’t have this issue as if I took the full 750 mg I felt very strange consistently and none of the other supplements in the mixture would seem to do this.