Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS ).
Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.
Vascular Disorders: venous thromboembolism
Miscellaneous: Inflammation and pain at the site of intramuscular injection.
Testosterone Replacement Therapy increases testosterone levels which affects the part of the brain (the hypothalamus and pituitary gland) which produces a chemical called gonadotropin-releasing hormone (GnRH). GnRH speaks with the pituitary gland to tell it to produce two other hormones: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). FSH tells your testicles to produce sperm cells while FH triggers the production of testosterone. This is where the natural problem of Low T occurs. If this cycle fails, your body quits producing testosterone and your begin experiencing fatigue, stubborn fat, trouble losing weight, decreased sex drive and more. During Testosterone Replacement Therapy (TRT) you may experience fertility issues because your body sees testosterone present.
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