Testosterone and body fat

An excessive food supply has resulted in an increasing prevalence of overweight and obesity, conditions accompanied by serious health problems. Several studies have confirmed the significant inverse correlation between testosterone and obesity. Indeed after decades of intense controversy, a consensus has emerged that androgens are important regulators of fat mass and distribution in mammals and that androgen status affects cellularity in vivo. The high correlation of testosterone levels with body composition and its contribution to the balance of lipid metabolism are also suggested by the fact that testosterone lowering is associated with important clinical disorders such as dyslipidemia, atherosclerosis, cardiovascular diseases, metabolic syndrome and diabetes. In contrast, testosterone supplementation therapy in hypogonadic men has been shown to improve the lipid profile by lowering cholesterol, blood sugar and insulin resistance. Leptin, ghrelin and adiponectin are some of the substances related to feeding as well as androgen regulation. Thus, complex and delicate mechanisms appear to link androgens with various tissues (liver, adipose tissue, muscles, coronary arteries and heart) and the subtle alteration of some of these interactions might be the cause of correlated diseases. This review underlines some aspects regarding the high correlations between testosterone physiology and body fat composition. J. Cell. Physiol. 227: 3744–3748, 2012. © 2012 Wiley Periodicals, Inc.

Hmmmm interesting. Funny you mention it because I was taking gaba not too long ago and it was in a mixture with some other stuff. Anyways, I think it was causing me to wake up kind of uncoordinated and feeling just kind of weird. Dissociative I guess you could say, which makes sense because it’s related to the NMDA receptors somehow I think. It supposedly “can’t” cross the blood brain barrier, at least this is repeated despite the fact that it can and does, it’s just an unreliable mechanism in which it does. Low levels of gaba were insinuated to absorb more in the brain also. I didn’t have this issue as if I took the full 750 mg I felt very strange consistently and none of the other supplements in the mixture would seem to do this.

In a recent paper published in the international, peer-reviewed journal PLoS ONE, Concordia University’s Sylvia Santosa, assistant professor in the Department of Exercise Science, shows that low testosterone levels lead to changes in fat cells in the lower body but not in the upper body.

The study sheds light on how testosterone controls where fat is stored and shows that men who have low levels of testosterone show a shift in how they store body fat. Like women, they store more fat in their hips and thighs.

To prove this, Santosa and co-author Michael Jensen from the Mayo Clinic in Minnesota analyzed the amount of stored fat that comes directly from food consumption by giving male study subjects a liquid meal with a radioactive tracer.

They later collected samples of fat from the abdomen and the thigh to see how much of the fat contained in the meal was stored and found that men with low testosterone stored more fat in the thigh than men with normal testosterone.

Santosa and Jensen also analyzed some of the proteins that break down and store fat. They found that abnormal protein levels provided clues as to how the presence of testosterone changes the functioning of fat cells.

It turns out that the levels of a protein involved in trapping fat within cells were much higher in the thigh cells of men with low testosterone levels, suggesting that testosterone controls body fat distribution by influencing the proteins that trap fat.

These findings can serve as a warning sign for many. While those with lower body fat are at less risk for diseases associated with obesity than those with upper body fat, those with low testosterone may have an imbalance in their fat-storage system, which can lead to unhealthy cells.

“The main focus for researchers right now is to understand why people are shaped the way they are,” says Santosa. “It’s only through this knowledge that we can progress to treatment and prevention.”

Partners in Research: This study was supported by funding from the National Center for Research Resources, the National Institutes of Health, the American Diabetes Association, the Natural Sciences and Engineering Council of Canada and the Canadian Diabetes Association.

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