But there is little evidence that testosterone therapy has any positive effect on heart health. A study in the Journal of Clinical Endocrinology & Metabolism examined the connection between testosterone and cardiovascular events in studies from 1970 and 2013. Researchers found that men with low testosterone levels may have a slightly elevated risk of developing or dying from heart disease. The study's senior author Dr. Johannes Ruige of Ghent University Hospital in Belgium, said testosterone replacement therapy did not have any beneficial effect on heart health.
Other side effects include increased risk of heart problems in older men with poor mobility, according to a 2009 study at Boston Medical Center. A 2017 study published in JAMA found that treatments increase coronary artery plaque volume. Additionally, the Food and Drug Administration (FDA) requires manufactures to include a notice on the labeling that states taking testosterone treatments can lead to possible increased risk of heart attacks and strokes. The FDA recommends that patients using testosterone should seek medical attention right away if they have these symptoms: