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That an oil could be extracted from anise and fennel had been known since the Renaissance by the German alchemist Hieronymus Brunschwig (ca. 1450 – ca. 1512), the German botanist Adam Lonicer (1528–1586), and the German physician Valerius Cordus (1515–1544), among others. [40] Anethole was first investigated chemically by the Swiss chemist Nicolas-Théodore de Saussure in 1820. [41] In 1832 the French chemist Jean Baptiste Dumas determined that the crystallizable components of anise oil and fennel oil were identical, and he determined anethole's empirical formula. [42] In 1845, the French chemist Charles Gerhardt coined the term anethol — from the Latin anethum (anise) + oleum (oil) — for the fundamental compound from which a family of related compounds was derived. [43] Although the German chemist Emil Erlenmeyer proposed the correct molecular structure for anethole in 1866, [44] it wasn't until 1872 that the structure was accepted as correct. [45]

The next document issued was a proposed rule dated June 17, 1994, which states, “FDA is issuing a notice of proposed rulemaking in the form of an amended tentative final monograph that would establish conditions under which OTC topical health-care antiseptic drug products are generally recognized as safe and effective and not misbranded. FDA is issuing this notice of proposed rulemaking on topical antimicrobial drug products after considering the public comments on that notice and other information in the administrative record for this rulemaking. FDA is also requesting data and information concerning the safety and effectiveness of topical antimicrobials for use as hand sanitizers or dips.” [70] In the 1994 update to the rule, TCS was effectively removed from the drug category which made it available for use in consumer products. [71]

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