These books make great birthday, holiday or anytime gifts for that hard-to-please fisherman! There's fisherman-friendly information about Florida's Gulf coast from Homosassa to Pensacola in the "Big Bend and Emerald Coast" book and information from Homosassa to the Everglades in the "Tampa Bay and Southwest Florida" book. Both include 'how-to' and 'where-to' fish, marine facilities, lodging and food, and a listing of local professional fishing guides. And, as a bonus, there's lots of information about fish species (and how to catch them), tackle, rigging, hiring a guide, party boats, and a list of offshore reefs and wrecks (with GPS coordinates). Find the books at local tackle shops and book stores, and from
...and don't forget the guide project sponsors!
Tibolone has tissue -selective estrogenic effects, with desirable effects in bone , the brain , and the vagina , and lack of undesirable action in the endometrium and breasts .  Its tissue selectivity is the result of metabolism , enzyme modulation (., of estrogen sulfatase and estrogen sulfotransferase ), and receptor modulation that vary in different target tissues, and differs mechanistically from that of selective estrogen receptor modulators (SERMs) such as tamoxifen , which produce their tissue selectivity via means of modulation of the ER.   As such, to distinguish it from SERMs, tibolone has been described as a "selective tissue estrogenic activity regulator" (STEAR),  and also as a "selective estrogen enzyme modulator" (SEEM).