Most ASD individuals exhibit a genetic tendency for undermethylation. A relative few exhibit a genetic tendency for overmethylation. However, it’s important to consider the impact of (1) inadequate diet and (2) inefficient digestion/absorption which is present in most of these individuals. Regardless of innate tendency for methylation, many ASD individuals are starved for all components of the SAM cycle and MTHF. In other words, they are deficient (across the board) in most nutrients. Two of the greatest deficiencies in ASD appear to be B-12 and methionine. B-12 is one of the most difficult vitamins to assimilate in healthy persons, and the situation is much worse if significant . tract problems exist. The principal source of methyl groups is methionine from dietary protein. However, most ASD children receive inadequate amounts of dietary protein AND are very inefficient in cleaving the complex proteins into the amino acid units to enable absorption. Folic acid is also in a deficiency state in many ASD children…… including children with a genetic tendency for overmethylation and folic acid overload.
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. 187 190 Importance of clinicians informing patients about the benefits and risks of taking antipsychotics during pregnancy (see Fetal/Neonatal Morbidity and Mortality under Cautions). 187 190 Importance of advising patients not to stop taking haloperidol if they become pregnant without consulting their clinician; abruptly discontinuing antipsychotic agents may cause complications. 190 Importance of advising patients not to breast-feed during haloperidol therapy. 187