VSonic GR07 Classic ($99) / GR07 Bass Edition ($130) – VSonic’s dynamic-driver flagship has been popular on the portable Hi-Fi scene for four years thanks to its ergonomic design and bio-cellulose dynamic drivers that offer excellent consistency across audio sources and produce sound that’s quite neutral, yet not lean or lacking in bass. There are more of both highs and lows compared to the HiFiMan RE-400 and Etymotic HF5, but the GR07 is still pretty darn balanced, and plenty great-sounding. The latest “Classic” version is available in 3 colors and priced at $99 while those looking for a little more bass will enjoy the equally capable GR07 Bass Edition. Read full review: VSonic GR07 / VSonic GR07 Bass Edition . Read impressions of the GR07 Classic here .
Concomitant use of pazopanib and simvastatin increases the incidence of ALT elevations. Results from a meta-analysis using pooled data from clinical studies with pazopanib show that ALT >3x ULN was reported in 126/895 (14%) of patients who did not use statins, compared with 11/41 (27%) of patients who had concomitant use of simvastatin (p = ). If a patient receiving concomitant simvastatin develops ALT elevations, follow guidelines for pazopanib posology and discontinue simvastatin (see section ). In addition, concomitant use of pazopanib and other statins should be undertaken with caution as there are insufficient data available to assess their impact on ALT levels. It cannot be excluded that pazopanib will affect the pharmacokinetics of other statins (. atorvastatin, fluvastatin, pravastatin, rosuvastatin).
Conductive hearing loss results from any condition in the outer or middle ear that interferes with sound passing to the inner ear. Excessive wax in the auditory canal, a ruptured eardrum, and other conditions of the outer or middle ear can produce conductive hearing loss. Although work-related conductive hearing loss is not common, it can occur when an accident results in a head injury or penetration of the eardrum by a sharp object, or by any event that ruptures the eardrum or breaks the ossicular chain formed by the small bones in the middle ear (., impulsive noise caused by explosives or firearms). Conductive hearing loss may be reversible through medical or surgical treatment. It is characterized by relatively uniformly reduced hearing across all frequencies in tests of the ear, with no reduction during hearing tests that transmit sound through bone conduction.