Aromatase inhibitors are the compounds that serve to reduce estradiol levels in blood by eliminating the production of estradiol through binding to and disabling the aromatase enzyme, which is responsible for the conversion (or aromatization) of androgens into estradiol. Suicidal aromatase inhibitors serve to permanently inhibit and disable the aromatase enzyme to which it is bound to. This renders the enzyme inactive forever. The body will eventually manufacture more aromatase enzymes, but the currently-bound enzymes are bound indefinitely, eliminating any risk for estrogen rebound. This is the main difference compared alongside two other major aromatase inhibitors: anastrozole and letrozole, which are non-suicidal aromatase inhibitors that are only bound to the aromatase enzyme for limited time periods. If a non-suicidal aromatase inhibitor is halted too abruptly, the circulating inhibited aromatase enzymes that have not been metabolized out of the body will then become free again, and begin aromatizing androgens into estrogens at an often rapid rate. This is not the case with Exos.
[ Editor's Note: Chryste Gaines, MBA, Olympic gold and bronze medal sprinter and former teammate of Marion Jones in the 2000 Sydney Olympic Games, stated the following in a Dec. 22, 2008 email to in response to the IOC ruling:
"We are being unfairly punished. If the drug testing agencies cannot determine if an athlete is taking performance enhancing drugs how are the teammates supposed to know?... It negates all the family functions, church functions, and social events we missed in the name of winning an Olympic medal." ]
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